关于人耳老鼠的论文~我只知道是曹谊林教授在1995年做成的,是一个标志性事件.但是不知道相关的论文有没有?请告诉我该论文
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关于人耳老鼠的论文~
我只知道是曹谊林教授在1995年做成的,是一个标志性事件.但是不知道相关的论文有没有?请告诉我该论文最早的出处(包括期刊名,时间).
我只知道是曹谊林教授在1995年做成的,是一个标志性事件.但是不知道相关的论文有没有?请告诉我该论文最早的出处(包括期刊名,时间).
![关于人耳老鼠的论文~我只知道是曹谊林教授在1995年做成的,是一个标志性事件.但是不知道相关的论文有没有?请告诉我该论文](/uploads/image/z/7812896-32-6.jpg?t=%E5%85%B3%E4%BA%8E%E4%BA%BA%E8%80%B3%E8%80%81%E9%BC%A0%E7%9A%84%E8%AE%BA%E6%96%87%7E%E6%88%91%E5%8F%AA%E7%9F%A5%E9%81%93%E6%98%AF%E6%9B%B9%E8%B0%8A%E6%9E%97%E6%95%99%E6%8E%88%E5%9C%A81995%E5%B9%B4%E5%81%9A%E6%88%90%E7%9A%84%2C%E6%98%AF%E4%B8%80%E4%B8%AA%E6%A0%87%E5%BF%97%E6%80%A7%E4%BA%8B%E4%BB%B6.%E4%BD%86%E6%98%AF%E4%B8%8D%E7%9F%A5%E9%81%93%E7%9B%B8%E5%85%B3%E7%9A%84%E8%AE%BA%E6%96%87%E6%9C%89%E6%B2%A1%E6%9C%89%3F%E8%AF%B7%E5%91%8A%E8%AF%89%E6%88%91%E8%AF%A5%E8%AE%BA%E6%96%87)
我能找到的最早的文献是1997年的.
Plastic & Reconstructive Surgery
August 1997 - Volume 100 - Issue 2 - pp 297-302
Articles
《Transplantation of Chondrocytes Utilizing a Polymer-Cell Construct to Produce Tissue-Engineered Cartilage in the Shape of a Human Ear》
Cao, Yilin M.D., Ph.D.; Vacanti, Joseph P. M.D.; Paige, Keith T. M.D.; Upton, Joseph M.D.; Vacanti, Charles A. M.D.
Abstract
This study evaluates the feasibility of growing tissue-engineered cartilage in the shape of a human ear using chondrocytes seeded onto a synthetic biodegradable polymer fashioned in the shape of a 3-year-old child's auricle. A polymer template was formed in the shape of a human auricle using a nonwoven mesh of polyglycolic acid molded after being immersed in a 1% solution of polylactic acid. Each polyglycolic acid-polylactic acid template was seeded with chondrocytes isolated from bovine articular cartilage and then implanted into subcutaneous pockets on the dorsa of 10 athymic mice. The three-dimensional structure was well maintained after removal of an external stent that had been applied for 4 weeks.
Specimens harvested 12 weeks after implantation and subjected to gross morphologic and histologic analysis demonstrated new cartilage formation. The overall geometry of the experimental specimens closely resembled the complex structure of the child's auricle.
These findings demonstrate that polyglycolic acid-polylactic acid constructs can be fabricated in a very intricate configuration and seeded with chondrocytes to generate new cartilage that would be useful in plastic and reconstructive surgery.
Plastic & Reconstructive Surgery
August 1997 - Volume 100 - Issue 2 - pp 297-302
Articles
《Transplantation of Chondrocytes Utilizing a Polymer-Cell Construct to Produce Tissue-Engineered Cartilage in the Shape of a Human Ear》
Cao, Yilin M.D., Ph.D.; Vacanti, Joseph P. M.D.; Paige, Keith T. M.D.; Upton, Joseph M.D.; Vacanti, Charles A. M.D.
Abstract
This study evaluates the feasibility of growing tissue-engineered cartilage in the shape of a human ear using chondrocytes seeded onto a synthetic biodegradable polymer fashioned in the shape of a 3-year-old child's auricle. A polymer template was formed in the shape of a human auricle using a nonwoven mesh of polyglycolic acid molded after being immersed in a 1% solution of polylactic acid. Each polyglycolic acid-polylactic acid template was seeded with chondrocytes isolated from bovine articular cartilage and then implanted into subcutaneous pockets on the dorsa of 10 athymic mice. The three-dimensional structure was well maintained after removal of an external stent that had been applied for 4 weeks.
Specimens harvested 12 weeks after implantation and subjected to gross morphologic and histologic analysis demonstrated new cartilage formation. The overall geometry of the experimental specimens closely resembled the complex structure of the child's auricle.
These findings demonstrate that polyglycolic acid-polylactic acid constructs can be fabricated in a very intricate configuration and seeded with chondrocytes to generate new cartilage that would be useful in plastic and reconstructive surgery.
关于人耳老鼠的论文~我只知道是曹谊林教授在1995年做成的,是一个标志性事件.但是不知道相关的论文有没有?请告诉我该论文
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