Ly-1翻译成抗体反应性克隆,

Ly-1翻译成抗体反应性克隆,

Ly-1又叫CD5,免疫学里同一个蛋白有各种奇怪的名字,一般都没什么实际意思.CD5是一个细胞表面的膜蛋白,在T细胞和一部分B细胞上表达,可以控制B细胞的激活.
再问： 不好意思，是Ly-1 Antibody Reactive Clone
再答： 哦。。 Ly-1 antibody reactive clone (LYAR), a zinc finger nucleolar protein highly expressed in undifferentiated ESCs, plays a critical role in maintaining ESC identity. 是胚胎干细胞里表达的一种细胞核内蛋白，在未分化的胚胎干细胞里高度表达，保持胚胎干细胞的状态。 看这篇文献 Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cells. Li H, Wang B, Yang A, Lu R, Wang W, Zhou Y, Shi G, Kwon SW, Zhao Y, Jin Y. Shanghai Stem Cell Institute, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
再问： 我就是看这篇文章时不知道这个抗体反应性克隆是什么意思
再答： 看这篇发现这个蛋白的文献，93年的,在上海干细胞 研究所的那篇文章的引用列表里是第21个。 LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. L Su, R J Hershberger, and I L Weissman 摘要里说 A cDNA encoding a novel zinc finger protein has been isolated from a mouse T-cell leukemia line on the basis of its expression of a Ly-1 epitope in a lambda gt11 library. The putative gene was mapped on mouse chromosome 1, closely linked to Idh-1, but not linked to the Ly-1 (CD5) gene. The cDNA is therefore named Ly-1 antibody reactive clone (LYAR).